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Home / Primary Antibodies

CTLA-4 Antibody / CD152 (V7700SAF)

SKU : BHA17126889

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NSJ Bioreagents

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Mfr.No.	V7700SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	This CTLA4 antibody is specific to the soluble form of the protein. CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	Amino acids CENAPNRARM were used as the immunogen for the CTLA4 antibody.
Isotype	Mouse IgG1, kappa
Species Reactivity	Mouse, Rat; Not suitable for Human samples testing.
Note	Optimal dilution of the antibody should be determined by the researcher.

Uniprot	P16410

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the CTLA4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	WB
Description	Western blot: 1-2ug/ml

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/ctla4-antibody-l4p2f5-f10-v7700" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17126889	V7700SAF-100UG	100 ug	$499		Add to Cart

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