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Home / Primary Antibodies

CSF3R Antibody / Colony Stimulating Factor 3 Receptor (R31006)

SKU : BHA17104525

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NSJ Bioreagents

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Mfr.No.	R31006
Clonality	Polyclonal
Description	Colony-Stimulating Factor 3 Receptor, Granulocyte also known as GCSFR or CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. By in situ hybridization using human CSF3R cDNA as a probe, Inazawa et al.(1991) localized the gene to 1p35-p34.3. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. Dong et al.(2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation. The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the middle region of human CSF3R (EPWQPGLHINQKCELRHK) was used as the immunogen for this CSF3R antibody.
Isotype	IgG
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	Q99062

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the CSF3R antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB
Dilution	Weste blot: 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104525	R31006	100 ug	$419		Add to Cart

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