The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. (provided by RefSeq).
Formulation
In ascites with 0.09% sodium azide
Host
Mouse
Immunogen Region
This CSF1R antibody was raised using purified His-tagged recombinant human CSF1R.
Isotype
Mouse IgM, k
Species Reactivity
Human
Note
Titration of the CSF1R antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Uniprot
P07333
Format
Ascites
Purity
Ascites
Storage
Aliquot the CSF1R antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.