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Home / Primary Antibodies

CRY1 Antibody

SKU : BHA10559065

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA096933
Alternative Names	PHLL1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL Morioka N,et al. (2010) J Pharmacol Sci.113(3):234-45. Fonseca F,et al. (2010) Mol Diagn Ther.14(3):171-8. Stratmann M,et al.(2010) Genes Dev.24(12):1317-28.
Host	Rabbit
Immunogen	Peptide sequence around aa.551~555 (S-Q-G-S-G) derived from Human CRY1.
Involvement In Disease	Delayed sleep phase syndrome (DSPS)
Raised In	Rabbit
Reactivity	Mouse
Regulatory	RUO
Relevance	Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK ; NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK ; NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL Morioka N,et al. (2010) J Pharmacol Sci.113(3):234-45. Fonseca F,et al. (2010) Mol Diagn Ther.14(3):171-8. Stratmann M,et al.(2010) Genes Dev.24(12):1317-28.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total CRY1 protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q16526
Database Links	HGNC:2384 OMIM:601933 KEGG:hsa:1407 STRING:9606.ENSP00000008527 UniGene:Hs.151573
Function	Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components
Protein Families	DNA photolyase class-1 family

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559065	CSB-PA096933	100ul	$297		Add to Cart

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