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Home / Antibodies

CRTC2 Antibody (R31094)

SKU : BHA17104587

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NSJ Bioreagents

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Mfr.No.	R31094
Clonality	Polyclonal
Description	CREB-Regulated Transcription Coactivator 2, also known as TORC2, is a protein that in humans is encoded by the CRTC2 gene. The Inteational Radiation Hybrid Mapping Consortium mapped the gene to chromosome 1. By cotransfection of TORC2 and reporter genes in HeLa cells, Iourgenko et al.(2003) found that it potently activated expression of genes driven by the IL8 promoter or a promoter carrying multiple CRE-like sequences. Liu et al.(2008) demonstrated that a fasting-inducible switch, consisting of the histone acetyltransferase p300 and the nutrient-sensing deacetylase sirtuin-1(SIRT1), maintains energy balance in mice through the sequential induction of CRTC2 and FOXO1. Using mice and primary mouse hepatocytes, Wang et al.(2009) found that the protein functioned as a dual sensor for endoplasmic reticulum(ER) stress and fasting signals.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the C-terminus of human CRTC2 (QDPHTFNHQNLTHCSRH) was used as the immunogen for this CRTC2 antibody.
Isotype	IgG
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	Q53ET0

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the CRTC2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB
Dilution	Weste blot: 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104587	R31094	100 ug	$419		Add to Cart

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