Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors "Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest."Budhu A.S., Noy N. Mol. Cell. Biol. 22:2632-2641(2002) "A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II." Sessler R.J., Noy N. Mol. Cell 18:343-353(2005)
Host
Rabbit
Immunogen
Peptide sequence around aa.87~91(K-W-E-S-E) derived from Human CRABP2
Raised In
Rabbit
Reactivity
Human, Rat
Regulatory
RUO
Relevance
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors "Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest."
Budhu A.S., Noy N. Mol. Cell. Biol. 22:2632-2641(2002) "A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II." Sessler R.J., Noy N. Mol. Cell 18:343-353(2005)
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CRABP2 protein.
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
Protein Families
Calycin superfamily, Fatty-acid binding protein (FABP) family
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.