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Home / Antibodies

COX2 Antibody / PTGS2 (V8362SAF)

SKU : BHA17127436

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NSJ Bioreagents

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Mfr.No.	V8362SAF-100UG
Clonality	Recombinant Rabbit Monoclonal
Description	Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Rabbit
Immunogen Region	A portion of amino acids 504-604 from the human protein was used as the immunogen for the recombinant COX-2 antibody.
Isotype	Rabbit IgG
Species Reactivity	Human
Note	Optimal dilution of the recombinant COX-2 antibody should be determined by the researcher.

Uniprot	P35354

Format	Purified
Purity	Protein A affinity chromatography
Storage	Store the recombinant COX-2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IHC-P
Description	Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/cox-2-antibody-cox2-3320r-v8362" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17127436	V8362SAF-100UG	100 ug	$499		Add to Cart

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