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Home / Primary Antibodies

COPS3 Antibody

SKU : BHA10559747

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA799923
Alternative Names	SGN3; COP9; SUBUNIT 3;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.George Z. Rassidakis, Clin. Cancer Res., Mar 2003; 9: 1121.Ricardo V. Lloyd, Am. J. Pathol., Mar 2002; 160: 1171.Shu Xiao, PNAS, Oct 2006; 103: 16448 - 16453.Alex Kudrin, J. Biol. Chem., Oct 2006; 281: 29641 - 29651.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human JAB1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. George Z. Rassidakis, Clin. Cancer Res., Mar 2003; 9: 1121. Ricardo V. Lloyd, Am. J. Pathol., Mar 2002; 160: 1171. Shu Xiao, PNAS, Oct 2006; 103: 16448 - 16453. Alex Kudrin, J. Biol. Chem., Oct 2006; 281: 29641 - 29651.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total JAB1 protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q9UNS2
Database Links	HGNC:2239 OMIM:604665 KEGG:hsa:8533 STRING:9606.ENSP00000268717 UniGene:Hs.6076
Function	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Protein Families	CSN3 family
Tissue Specificity	Widely expressed. Expressed at high level in heart and skeletal muscle.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559747	CSB-PA799923	100ul	$297		Add to Cart

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