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Home / Antibodies

COMT Antibody

SKU : BHA10558317

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA443797
Alternative Names	Catechol O-methyltransferase; membrane-bound form; catechol-O-methyltransferase; EC 2.1.1.6; MB-COMT
Categories	Primary Antibodies
Clonality	polyclonal
Description	Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.Lundstroem K., DNA Cell Biol. 10:181-189(1991).Bertocci B., Proc. Natl. Acad. Sci. U.S.A. 88:1416-1420(1991).Tenhunen J., Eur. J. Biochem. 223:1049-1059(1994).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human COMT.
Involvement In Disease	Schizophrenia (SCZD)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Lundstroem K., DNA Cell Biol. 10:181-189(1991). Bertocci B., Proc. Natl. Acad. Sci. U.S.A. 88:1416-1420(1991). Tenhunen J., Eur. J. Biochem. 223:1049-1059(1994).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total COMT protein.
Subcellular Location	Isoform Soluble: Cytoplasm, SUBCELLULAR LOCATION: Isoform Membrane-bound: Cell membrane, Single-pass type II membrane protein, Extracellular side

Uniprot	P21964
Database Links	HGNC:2228 OMIM:103780 KEGG:hsa:1312 STRING:9606.ENSP00000354511 UniGene:Hs.370408
Function	Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Protein Families	Class I-like SAM-binding methyltransferase superfamily, Cation-dependent O-methyltransferase family
Tissue Specificity	Brain, liver, placenta, lymphocytes and erythrocytes.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558317	CSB-PA443797	100ul	$297		Add to Cart

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