In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.Bentley D.R., Nature 441:315-321(2006).Henzel W.J., Protein Sci. 13:2819-2824(2004).Smith R.D., J. Proteome Res. 4:2070-2080(2005).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human CNTN2.
Involvement In Disease
Epilepsy, familial adult myoclonic, 5 (FAME5)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.
Bentley D.R., Nature 441:315-321(2006). Henzel W.J., Protein Sci. 13:2819-2824(2004). Smith R.D., J. Proteome Res. 4:2070-2080(2005).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CNTN2 protein.
In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.
Protein Families
Immunoglobulin superfamily, Contactin family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.