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Home / Antibodies

CNTFR Antibody

SKU : BHA10557644

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA204475
Alternative Names	ciliary neurotrophic factor receptor
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
Host	Rabbit
Immunogen	Fusion protein corresponding to a region derived from 23-342 amino acids of Human ciliary neurotrophic factor receptor
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total CNTFR protein.
Subcellular Location	Cell membrane, Lipid-anchor, GPI-anchor

Uniprot	P26992
Database Links	HGNC:2170 OMIM:118946 KEGG:hsa:1271 STRING:9606.ENSP00000242338 UniGene:Hs.129966
Function	Binds to CNTF. The alpha subunit provides the receptor specificity.
Pathway	Jak-STAT signaling pathway
Protein Families	Type I cytokine receptor family, Type 3 subfamily
Tissue Specificity	Nervous system and skeletal muscle.

Buffer	Supplied at 0.5mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Form	Supplied at 0.5mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Format	liquid
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:2000

Tested Application

ELISA,WB;WB:1:500-1:2000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557644	CSB-PA204475	100ul	$297		Add to Cart

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