ACDP2; ancient conserved domain protein 2; cyclin M2; metal transporter CNNM2;
Categories
Primary Antibodies
Clonality
polyclonal
Description
Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg2+ > Co2+ > Mn2+ > Sr2+ > Ba2+ > Cu2+ > Fe2+ By similarity.Ota T., Nat. Genet. 36:40-45(2004).Deloukas P., Nature 429:375-381(2004).Wang C.-Y., Gene 306:37-44(2003).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human CNNM2.
Involvement In Disease
Hypomagnesemia 6 (HOMG6); Hypomagnesemia, seizures, and mental retardation (HOMGSMR)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg2+ > Co2+ > Mn2+ > Sr2+ > Ba2+ > Cu2+ > Fe2+ By similarity.
Ota T., Nat. Genet. 36:40-45(2004). Deloukas P., Nature 429:375-381(2004). Wang C.-Y., Gene 306:37-44(2003).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CNNM2 protein.
Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).
Protein Families
ACDP family
Tissue Specificity
Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick ascending limb of Henle loop.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.