Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.Masuda H., J. Biochem. 120:415-424(1996).Kuromitsu J., Mol. Cell. Biol. 17:707-712(1997).Gevaert K., Nat. Biotechnol. 21:566-569(2003).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human CNN2.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Masuda H., J. Biochem. 120:415-424(1996). Kuromitsu J., Mol. Cell. Biol. 17:707-712(1997). Gevaert K., Nat. Biotechnol. 21:566-569(2003).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CNN2 protein.
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Protein Families
Calponin family
Tissue Specificity
Heart and smooth muscle.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.