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Home / Antibodies

CNGA1 Antibody

SKU : BHA10558335

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA265137
Alternative Names	cGMP-gated cation channel alpha 1; CNCG; CNCG1; CNG channel alpha 1; CNG-1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.Pittler S.J., J. Biol. Chem. 267:6257-6262(1992).Dhallan R.S., J. Neurosci. 12:3248-3256(1992).Ota T., Nat. Genet. 36:40-45(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human CNGA1.
Involvement In Disease	Retinitis pigmentosa 49 (RP49)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Pittler S.J., J. Biol. Chem. 267:6257-6262(1992). Dhallan R.S., J. Neurosci. 12:3248-3256(1992). Ota T., Nat. Genet. 36:40-45(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total CNGA1 protein.
Subcellular Location	Membrane, Multi-pass membrane protein

Uniprot	P29973
Database Links	HGNC:2148 OMIM:123825 KEGG:hsa:1259 STRING:9606.ENSP00000384264 UniGene:Hs.1323
Function	Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Pathway	cAMP signaling pathway cGMP-PKG signaling pathway
Protein Families	Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA1 subfamily
Tissue Specificity	Rod cells in the retina.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558335	CSB-PA265137	100ul	$297		Add to Cart

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