Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.Van Rompay A.R., Mol. Pharmacol. 56:562-569(1999).Pearman A.T., Life Sci. 69:2361-2370(2001).Liou J.-Y., Cancer Res. 62:1624-1631(2002).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human KCY.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
Van Rompay A.R., Mol. Pharmacol. 56:562-569(1999). Pearman A.T., Life Sci. 69:2361-2370(2001). Liou J.-Y., Cancer Res. 62:1624-1631(2002).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total KCY protein.
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
Protein Families
Adenylate kinase family, UMP-CMP kinase subfamily
Tissue Specificity
Ubiquitously expressed.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.