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Home / Primary Antibodies

Clostridium difficile Toxin A Antibody (V8285SAF)

SKU : BHA17127371

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NSJ Bioreagents

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Mfr.No.	V8285SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	This mAb reacts with C. difficile Toxin A, but not with Cholera subunit a, Cholera toxin, Pseudomonas aeruginosa exotoxin A, H-LT, P-LT. Clostridium difficile is a major nosocomial pathogen that causes antibiotic- associated colitis. Clostridium difficile mediates inflammatory diarrhea by releasing two large protein enterotoxins (Toxin A and Toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. Clostridium difficile Toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. Clostridium difficile Toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21, leading to cytochrome c release and caspase-3 activation through Bak activation.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	C. difficile Toxin A was used as the immunogen for the Clostridium difficile Toxin A antibody.
Isotype	Mouse IgG1, kappa
Species Reactivity	Clostridium difficile
Note	Optimal dilution of the antibody should be determined by the researcher.

Uniprot	P16154

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the Clostridium difficile Toxin A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	ELISA, IF
Description	ELISA (order BSA-free format for coating),Immunofluorescence: 1-2ug/ml

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/clostridium-difficile-toxin-a-antibody-253-422-v8285" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17127371	V8285SAF-100UG	100 ug	$499		Add to Cart

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