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Home / Antibodies

CLN5 Antibody

SKU : BHA10558334

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA128789
Alternative Names	Ceroid-lipofuscinosis neuronal protein 5; Protein CLN5;
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.Savukoski M., Nat. Genet. 19:286-288(1998).Dunham A., Nature 428:522-528(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human CLN5.
Involvement In Disease	Ceroid lipofuscinosis, neuronal, 5 (CLN5)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. Savukoski M., Nat. Genet. 19:286-288(1998). Dunham A., Nature 428:522-528(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total CLN5 protein.
Subcellular Location	Ceroid-lipofuscinosis neuronal protein 5, secreted form: Lysosome, SUBCELLULAR LOCATION: Ceroid-lipofuscinosis neuronal protein 5: Membrane, Single-pass type II membrane protein

Uniprot	O75503
Database Links	HGNC:2076 OMIM:256731 KEGG:hsa:1203 STRING:9606.ENSP00000366673 UniGene:Hs.30213
Function	Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane
Protein Families	CLN5 family
Tissue Specificity	Ubiquitous.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558334	CSB-PA128789	100ul	$297		Add to Cart

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