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Home / Antibodies

CLDN1 (Ab-210) Antibody

SKU : BHA10559152

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA133727
Alternative Names	CLD1; CLDN1; SEMP1; Senescence-associated epithelial membrane protein; UNQ481/PRO944
Categories	Primary Antibodies
Clonality	polyclonal
Description	Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.Swisshelm K.L., Gene 226:285-295(1999).Halford S., Cytogenet. Cell Genet. 88:217-217(2000).Kraemer F., Hum. Genet. 107:249-256(2000).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human Claudin 1 around the phosphorylation site of tyrosine 210 (G-K-D-Y(p)-V).
Involvement In Disease	Ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (). CLDN1 acts as a coreceptor for HCV entry into hepatic cells. Swisshelm K.L., Gene 226:285-295(1999). Halford S., Cytogenet. Cell Genet. 88:217-217(2000). Kraemer F., Hum. Genet. 107:249-256(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Claudin 1 protein.
Subcellular Location	Cell junction, tight junction, Cell membrane, Multi-pass membrane protein, Basolateral cell membrane

Uniprot	O95832
Database Links	HGNC:2032 OMIM:603718 KEGG:hsa:9076 STRING:9606.ENSP00000295522 UniGene:Hs.439060
Function	Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions
Protein Families	Claudin family
Tissue Specificity	Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559152	CSB-PA133727	100ul	$297		Add to Cart

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