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Home / Primary Antibodies

CHST14 Antibody, HRP conjugated

SKU : BHA10561519

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA839851LB01HU
Alternative Names	Carbohydrate sulfotransferase 14 (EC 2.8.2.35) (Dermatan 4-sulfotransferase 1) (D4ST-1) (hD4ST1), CHST14, D4ST1
Categories	Primary Antibodies
Clonality	polyclonal
Immunogen	Recombinant Human Carbohydrate sulfotransferase 14 protein (70-133AA)
Involvement In Disease	Ehlers-Danlos syndrome, musculocontractural type 1 (EDSMC1)
Isotype	IgG
Raised In	Rabbit
Reactivity	Human
Relevance	Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development.
Subcellular Location	Golgi apparatus membrane, Single-pass type II membrane protein

Uniprot	Q8NCH0
Database Links	HGNC:24464 OMIM:601776 KEGG:hsa:113189 STRING:9606.ENSP00000307297 UniGene:Hs.442449
Function	Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development.
Protein Families	Sulfotransferase 2 family
Research Area	Others
Tissue Specificity	Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid.

Form	Liquid
Purification	>95%, Protein G purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Description	ELISA
Tested Application	ELISA

Datasheet
ELISA Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10561519	CSB-PA839851LB01HU	100ug	$299		Add to Cart
BHA10561519	CSB-PA839851LB01HU	50ug	$166		Add to Cart

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