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CHP2 Antibody

SKU : BHA10558286

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA869859
Alternative Names	Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520; CHP2; HCA520;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.Loftus B.J., Genomics 60:295-308(1999).Wang Y., J. Immunol. 169:1102-1109(2002).Pang T., J. Biol. Chem. 277:43771-43777(2002).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of HumanCHP2.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. Loftus B.J., Genomics 60:295-308(1999). Wang Y., J. Immunol. 169:1102-1109(2002). Pang T., J. Biol. Chem. 277:43771-43777(2002).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total CHP2 protein.
Subcellular Location	Nucleus, Cytoplasm, Cell membrane

Uniprot	O43745
Database Links	HGNC:24927 KEGG:hsa:63928 STRING:9606.ENSP00000300113 UniGene:Hs.178589
Function	Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
Protein Families	Calcineurin regulatory subunit family, CHP subfamily
Tissue Specificity	Expressed in malignantly transformed cells but not detected in normal tissues.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558286	CSB-PA869859	100ul	$297		Add to Cart

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