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Home / Antibodies

CHP2 Antibody / Calcineurin B homologous protein 2 (V8074SAF)

SKU : BHA17127199

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NSJ Bioreagents

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Mfr.No.	V8074SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	CHP2 (calcineurin B homologous protein 2), also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	Recombinant human full-length protein was used as the immunogen for the CHP2 antibody.
Isotype	Mouse IgG2c, kappa
Species Reactivity	Human
Note	Optimal dilution of the antibody should be determined by the researcher.

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the CHP2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	WB, IF
Description	Weste blot: 1-2ug/ml,Immunofluorescence: 1-2ug/ml

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/chp2-antibody-calcineurin-b-homologous-protein-2-cptc-chp2-1-v8074" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17127199	V8074SAF-100UG	100 ug	$499		Add to Cart

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