Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.Yamazaki N., J. Biol. Chem. 275:31739-31746(2000).Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).Yu L.-R., J. Proteome Res. 6:4150-4162(2007).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human CHKB.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.
Yamazaki N., J. Biol. Chem. 275:31739-31746(2000). Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004). Yu L.-R., J. Proteome Res. 6:4150-4162(2007).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CHKB protein.
Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.
Protein Families
Choline/ethanolamine kinase family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.