centrosomal protein of 55 kDa; up-regulated in colon cancer 6;
Categories
Primary Antibodies
Clonality
polyclonal
Description
Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.Martinez-Garay I., Genomics 87:243-253(2006).Shimokawa T., Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.Totoki Y., Submitted (APR-2005) to the EMBL/GenBank/DDBJ database.
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human CEP55.
Involvement In Disease
Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly (MARCH)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.
Martinez-Garay I., Genomics 87:243-253(2006). Shimokawa T., Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases. Totoki Y., Submitted (APR-2005) to the EMBL/GenBank/DDBJ database.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CEP55 protein.
Subcellular Location
Cytoplasm, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cleavage furrow, Midbody, Midbody ring
Expressed in embryonic brain (PubMed:28264986). Expressed in fetal brain ganglionic eminence, kidney tubules and multinucleate neurons in the temporal cortex (PubMed:28264986). Expressed in adult brain, cerebellum, kidney tubules, intestine and muscles (a
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.