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Home / Antibodies

CEP290 Antibody

SKU : BHA10558323

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA758165
Alternative Names	CE290; centrosomal protein Cep290; CTCL tumor antigen se2-2; JBTS5; JBTS6
Categories	Primary Antibodies
Clonality	polyclonal
Description	Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition By similarity. Activates ATF4-mediated transcription. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes.ayer J.A., Nat. Genet. 38:674-681(2006).Nagase T., DNA Res. 4:141-150(1997).Scherer S.E., Nature 440:346-351(2006).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human CEP290.
Involvement In Disease	Joubert syndrome 5 (JBTS5); Senior-Loken syndrome 6 (SLSN6); Leber congenital amaurosis 10 (LCA10); Meckel syndrome 4 (MKS4); Bardet-Biedl syndrome 14 (BBS14)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition By similarity. Activates ATF4-mediated transcription. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. ayer J.A., Nat. Genet. 38:674-681(2006). Nagase T., DNA Res. 4:141-150(1997). Scherer S.E., Nature 440:346-351(2006).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total CEP290 protein.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite, Nucleus, Cell projection, cilium, Cytoplasm, cytoskeleton, cilium basal body, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, Cytoplasmic vesicle

Uniprot	O15078
Database Links	HGNC:29021 OMIM:610142 KEGG:hsa:80184 STRING:9606.ENSP00000448012 UniGene:Hs.150444
Function	Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110
Tissue Specificity	Ubiquitous. Expressed strongly in placenta and weakly in brain.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558323	CSB-PA758165	100ul	$297		Add to Cart

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