AGP/EBP; C/EBP beta; C/EBP-related protein 2; CCAAT/enhancer binding protein beta; CEBPB
Categories
Primary Antibodies
Clonality
polyclonal
Description
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Plays an important role in adipose tissue differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG) as well as other adipogenesis key player genes. Isoform 3:acts as a dominant negative through heterodimerization with isoform 2.Akira S., EMBO J. 9:1897-1906(1990).Wan D., Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).Deloukas P., Nature 414:865-871(2001).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human CEBPB.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Plays an important role in adipose tissue differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG) as well as other adipogenesis key player genes. Isoform 3:acts as a dominant negative through heterodimerization with isoform 2.
Akira S., EMBO J. 9:1897-1906(1990). Wan D., Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004). Deloukas P., Nature 414:865-871(2001).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CEBPB protein.