Cyclin-Dependent Kinase 5, is also know as PSSALRE. The p34(CDC2) protein kinase regulates important transitions in the eukaryotic cell cycle. Cdk5 expression is in all human tissues and cell lines tested. The the gene is mapped to chromosome 7q36. Cyclin-dependent kinase 5 is predominantly expressed in neurons where it phosphorylates both high molecular weight neurofilaments and microtubule-associated protein tau. It is required for proper development of the mammalian central nervous system. To be activated, Cdk5 must associate with its regulatory subunit, p35(CDK5R1). It can phosphorylate DARPP32 at threonine-75, converting it into an inhibitor of PKA.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the C-terminus of human Cdk5 (QRISAEEALQHPYFSDFCPP) was used as the immunogen for this Cdk5 antibody (100% homologous in human, mouse and rat).
Isotype
IgG
Predicted Reactivity
Human, Mouse, Rat
Reactivity
Human, Mouse, Rat
Recombinant
No
Uniprot
Q00535
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the Cdk5 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.