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CDH1 Antibody

SKU : BHA10557541

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA795479
Alternative Names	CDH1; CDHE; UVO
Categories	Primary Antibodies
Clonality	polyclonal
Description	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin a-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. Baki L.et.al(2001)Proc. Natl. Acad. Sci. U.S.A. 98:2381-2386Makagiansar I.T.et.al(2002)J. Biol. Chem. 277:16002-16010Agiostratidou G. (2006)J. Neurochem. 96:1182-1188
Host	Rabbit
Immunogen	Peptide sequence around aa.864~868(E-W-G-N-R) derived from Human E-Cadherin.
Involvement In Disease	Hereditary diffuse gastric cancer (HDGC); Endometrial cancer (ENDMC); Ovarian cancer (OC); Breast cancer, lobular (LBC); Blepharocheilodontic syndrome 1 (BCDS1)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin a-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. Baki L.et.al(2001)Proc. Natl. Acad. Sci. U.S.A. 98:2381-2386 Makagiansar I.T.et.al(2002)J. Biol. Chem. 277:16002-16010 Agiostratidou G. (2006)J. Neurochem. 96:1182-1188
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total E-Cadherin protein.
Subcellular Location	Cell junction, Cell membrane, Single-pass type I membrane protein, Endosome, Golgi apparatus, trans-Golgi network

Uniprot	P12830
Database Links	HGNC:1748 OMIM:119580 KEGG:hsa:999 STRING:9606.ENSP00000261769 UniGene:Hs.461086
Function	Cadherins are calcium-dependent cell adhesion proteins
Pathway	Hippo signaling pathway Adherens junction Apelin signaling pathway Rap1 signaling pathway
Tissue Specificity	Non-neural epithelial tissues.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557541	CSB-PA795479	100ul	$297		Add to Cart

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