CC37; Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37; p50Cdc37;
Categories
Primary Antibodies
Clonality
polyclonal
Description
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.Stepanova L., Genes Dev. 10:1491-1502(1996).Dai K., J. Biol. Chem. 271:22030-22034(1996).Lamphere L., Oncogene 14:1999-2004(1997).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human p50 CDC37.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.
Stepanova L., Genes Dev. 10:1491-1502(1996). Dai K., J. Biol. Chem. 271:22030-22034(1996). Lamphere L., Oncogene 14:1999-2004(1997).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total p50 CDC37 protein.
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity
Pathway
PI3K-Akt signaling pathway
Protein Families
CDC37 family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.