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Home / Antibodies

CDC14A Antibody

SKU : BHA10558841

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA154120
Alternative Names	CC14A; CDC10 (cell division cycle 10; S. cerevisiae; homolog); cdc14
Categories	Primary Antibodies
Clonality	polyclonal
Description	Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.Li L., J. Biol. Chem. 272:29403-29406(1997).Wong A.K.C., Genomics 59:248-251(1999).Gregory S.G., Nature 441:315-321(2006).
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human CC14A.
Involvement In Disease	Deafness, autosomal recessive, 105 (DFNB105)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Li L., J. Biol. Chem. 272:29403-29406(1997). Wong A.K.C., Genomics 59:248-251(1999). Gregory S.G., Nature 441:315-321(2006).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total CC14A protein.
Subcellular Location	Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle pole, Cytoplasm, cytoskeleton, spindle, Cell projection, kinocilium

Uniprot	Q9UNH5
Database Links	HGNC:1718 OMIM:603504 KEGG:hsa:8556 STRING:9606.ENSP00000354916 UniGene:Hs.127411
Function	Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.
Pathway	Cell cycle
Protein Families	Protein-tyrosine phosphatase family, Non-receptor class CDC14 subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558841	CSB-PA154120	100ul	$297		Add to Cart

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