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Home / Primary Antibodies

CD79A Antibody

SKU : BHA10558887

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA165334
Alternative Names	B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Surface IgM-associated protein; Membrane-bound immunoglobulin-associated protein
Categories	Primary Antibodies
Clonality	polyclonal
Description	Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.Leduc I., Clin. Exp. Immunol. 90:141-146(1992).Mueller B.S., Eur. J. Immunol. 22:1621-1625(1992).Flaswinkel H., Immunogenetics 36:266-269(1992).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human CD79A.
Involvement In Disease	Agammaglobulinemia 3, autosomal recessive (AGM3)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells. Leduc I., Clin. Exp. Immunol. 90:141-146(1992). Mueller B.S., Eur. J. Immunol. 22:1621-1625(1992). Flaswinkel H., Immunogenetics 36:266-269(1992).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total CD79A protein.
Subcellular Location	Cell membrane, Single-pass type I membrane protein

Uniprot	P11912
Database Links	HGNC:1698 OMIM:112205 KEGG:hsa:973 STRING:9606.ENSP00000221972 UniGene:Hs.631567
Function	Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
Pathway	B cell receptor signaling pathway
Tissue Specificity	B-cells.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558887	CSB-PA165334	100ul	$297		Add to Cart

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