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Home / Antibodies

CD73 Antibody (V7588BTN)

SKU : BHA17126752

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NSJ Bioreagents

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Mfr.No.	V7588BTN
Clonality	Monoclonal (mouse origin)
Description	CD73 is a membrane-bound extracellular enzyme overexpressed in several cancer types. Its expression has been linked to poor prognosis in melanoma, colorectal, gastric, triple negative breast cancer, and to a pro-metastatic phenotype in prostate cancer. Together with CD39, it plays a major role in promoting immunosuppression through the pathway degrading adenosine triphosphate (ATP) into adenosine. Within the tumor microenvironment, ATP promotes immune cell-mediated killing of cancer cells. In contrast, adenosine accumulation causes immune suppression, dysregulation of immune cell infiltrates and stimulates angiogenesis resulting in tumor spreading. CD73 is active on the last step of the degradation pathway, where it is the enzyme that actually degrades AMP into adenosine. CD73-blockade promotes anti-tumor immunity by reducing adenosine accumulation. Accordingly, anti-CD73 mAbs stimulate anti-tumor immunity and reduce tumor metastasis in mouse tumor models, and could enhance the efficacy of treatment with anti-PD1 or anti-CTLA4 antibodies.
Formulation	0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Host	Mouse
Immunogen Region	Recombinant full-length human NT5E protein was used as the immunogen for the CD73 antibody.
Isotype	Mouse IgG1, kappa
Species Reactivity	Human
Note	Optimal dilution of the CD73 antibody should be determined by the researcher.

Uniprot	P21589

Format	Biotin Conjugate
Purity	Protein G affinity chromatography
Storage	Store the CD73 antibody at 2-8oC (up to one month) or aliquot and store at -20oC (longer term).

Applications	ELISA, FACS, IF, WB, IHC-P
Description	ELISA: order Ab without BSA for coating,Flow cytometry: 2-4ug/million cells in 0.1ml,Immunofluorescence: 2-4ug/ml,Western blot: 2-4ug/ml,Immunohistochemistry (FFPE): 2-4ug/ml for 30 minutes at RT

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/cd73-antibody-nt5e-2646-v7588btn" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17126752	V7588BTN	500 ul	$499		Add to Cart

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