CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.
Formulation
1 mg/ml in 1X PBS; BSA free, sodium azide free
Host
Mouse
Immunogen Region
A CD8+ cytotoxic T-cell clone was used as the immunogen for the CD6 antibody.
Isotype
Mouse IgG1, kappa
Species Reactivity
Human, Mouse
Note
Optimal dilution of the CD6 antibody should be determined by the researcher.
Uniprot
P30203
Format
Purified
Purity
Protein G affinity chromatography
Storage
Store the CD6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).