Involved in cell adhesion. Binds to CD166.Sakaki Y., Nature 440:497-500(2006).Rudd C.E., J. Biol. Chem. 266:7137-7143(1991)Aruffo A., J. Exp. Med. 177:219-223(1993)..
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human CD6.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Involved in cell adhesion. Binds to CD166.
Sakaki Y., Nature 440:497-500(2006). Rudd C.E., J. Biol. Chem. 266:7137-7143(1991) Aruffo A., J. Exp. Med. 177:219-223(1993)..
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total CD6 protein.
Subcellular Location
Cell membrane, Single-pass type I membrane protein, Note=Detected at the immunological synapse, ie, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806), Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938), SUBCELLULAR LOCATION: Soluble CD6: Secreted
Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166
Tissue Specificity
Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detect
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.