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Home / Antibodies

CD53 Antibody (V3018SAF)

SKU : BHA17124621

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NSJ Bioreagents

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Mfr.No.	V3018SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	Recognizes a protein of 33-55kDa, identified as CD53 (Workshop V; Code CD53.1). CD53 is expressed on monocytes, and macrophages, granulocytes, dendritic cells, osteoblasts and osteoclasts, NK cells, and on T- and B-cells from every stage of differentiation but is absent from platelets, erythrocytes, and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins, including CD9, CD37, CD63, CD81, and CD82. It associates with integrins, MHC class II molecules, and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells, monocytes, and granulocytes and activation of the monocyte oxidative burst.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	Human Sezary cells were used as the immunogen for the CD53 antibody.
Isotype	Mouse IgG2b, kappa
Species Reactivity	Human
Note	Optimal dilution of the CD53 antibody should be determined by the researcher.

Uniprot	P19397

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the CD53 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	Functional studies, FACS, IF
Description	Functional studies (order BSA/sodium azide-free format),Flow cytometry: 0.5-1ug/million cells,Immunofluorescence: 0.5-1ug/ml

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17124621	V3018SAF-100UG	100 ug	$499		Add to Cart

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