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Home / Antibodies

CD45 Antibody (Leukocyte marker) (V2400)

SKU : BHA17111821

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NSJ Bioreagents

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Mfr.No.	V2400, V2400-20UG, V2400-100UG
Clonality	Monoclonal
Description	CD45R, also designated CD45, B220, LCA and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Along with other members of the PTP family, it regulates a number of cellular processes including cell differentiation, growth and mitotic cycle, and is an essential regulator of B- and T-cell antigen receptor-mediated activation.<p>Multiple isoforms of CD45 are distributed throughout the immune system and arise due to alteative splicing of exons located in the N-terminus. CD45RA contains the A exon and is a naive T-cell marker which may help prevent autoimmune disease. CD45RB contains B and stains most leukemias and lymphomas. CD45RC contains C and stains thymocytes, monocytes and dendritic cells. CD45RO doesn't contain A, B or C and is a marker of activated T-cells that can be used to classify and diagnose and classify lymphomas. This antibody will bind to all CD45 isoforms. The variation in these isoforms is localized to the extracellular domain, with the intracellular domain being conserved. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
Formulation	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Host	Mouse
Immunogen Region	Stimulated human leukocytes were used as the immunogen for the LCA antibody.
Isotype	IgG1,kappa
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No
Subcellular Location	Cell surface and cytoplasmic

Uniprot	P08575
Clone No	SPM496

Concentration	0.2 mg/ml
Format	Purified
Purification	Protein G affinity chromatography
Storage	LCA antibody (with azide) can be stored at 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Applications	IHC-P
Dilution	Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

Product Manual	Data Sheet

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17111821-1	V2400-20UG	20ug	$219		Add to Cart
BHA17111821-2	V2400-100UG	100ug	$499		Add to Cart

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