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Home / Primary Antibodies

CD137 Antibody / 4-1BB / TNFRSF9 (V8353SAF)

SKU : BHA17127428

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NSJ Bioreagents

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Mfr.No.	V8353SAF-100UG
Clonality	Monoclonal (rat origin)
Description	CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivowhen administered in combination with immune checkpoint inhibitors.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Rat
Immunogen Region	A murine CD137 human Fc fusion protein was used as the immunogen for the CD137 antibody.
Isotype	Rat IgG2a, kappa
Species Reactivity	Mouse
Note	Optimal dilution of the antibody should be determined by the researcher.

Uniprot	P20334

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the CD137 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	Functional Studies, FACS, IF
Description	Functional Studies (order BSA/azide-free format),Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/cd137-antibody-lob12-v8353" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17127428	V8353SAF-100UG	100 ug	$499		Add to Cart

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