CD137 belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. It is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma.
A portion of amino acids 19-188 from the human protein was used as the immunogen for the CD137 antibody.
Isotype
Mouse IgG1, kappa
Species Reactivity
Human
Note
Optimal dilution of the CD137 antibody should be determined by the researcher.
Uniprot
Q07011
Format
Biotin Conjugate
Purity
Protein G affinity chromatography
Storage
Store the CD137 antibody at 2-8oC (up to one month) or aliquot and store at -20oC (longer term).
Applications
ELISA, IF, FACS, IHC-P
Description
ELISA (order Ab without BSA for coating),Immunofluorescence: 2-4ug/ml,Flow cytometry: 2-4ug/million cells,Immunohistochemistry (FFPE): 2-4ug/ml for 30 minutes at RT