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Home / Primary Antibodies

CD10 Antibody / Neprilysin (V3870SAF)

SKU : BHA17125691

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NSJ Bioreagents

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Mfr.No.	V3870SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	Neprilysin, also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme that in humans is encoded by the MME gene. CD10 is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. It also degrades the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface.CD10 is expressed in a wide variety of tissues and is particularly abundant in kidney. It is also a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. (Wiki)
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	A portion of amino acids 297-483 from the human protein was used as the immunogen for the CD10 antibody.
Isotype	Mouse IgG2c, kappa
Species Reactivity	Human
Note	The stated application concentrations are suggested starting points. Titration of the CD10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Uniprot	P08473

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the CD10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	WB, IHC-P
Description	Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT,Weste blot: 1-2ug/ml

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17125691	V3870SAF-100UG	100 ug	$499		Add to Cart

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