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Home / Primary Antibodies

CCR5 Antibody

SKU : BHA10557595

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA572290
Alternative Names	CKR5; CD195; CKR-5
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor for a number of inflammatory CC-chemokines including MIP-1-a, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.Samson M., Labbe O., Mollereau C. Biochemistry 35:3362-3367(1996)Raport C.J., Gosling J., Schweichart V.L. J. Biol. Chem. 271:17161-17166(1996) Combadiere C., Ahuja S.K., Tiffany H.L., Murphy P.M.J. Leukoc. Biol. 60:147-152(1996)
Host	Rabbit
Immunogen	Peptide sequence around aa.11~15(D-I-N-Y-Y) derived from Human CCR5(CD195)., Peptide sequence around aa.11~15(D-I-N-Y-Y) derived from Human CCR5(CD195).
Involvement In Disease	Diabetes mellitus, insulin-dependent, 22 (IDDM22)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Receptor for a number of inflammatory CC-chemokines including MIP-1-a, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. Samson M., Labbe O., Mollereau C. Biochemistry 35:3362-3367(1996) Raport C.J., Gosling J., Schweichart V.L. J. Biol. Chem. 271:17161-17166(1996) Combadiere C., Ahuja S.K., Tiffany H.L., Murphy P.M.J. Leukoc. Biol. 60:147-152(1996)
Species	Homo Sapiens (Human), Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total CCR5(CD195) protein., The antibody detects endogenous level of total CCR5(CD195) protein.
Subcellular Location	Cell membrane, Multi-pass membrane protein

Uniprot	P51681
Database Links	HGNC:1606 OMIM:601373 KEGG:hsa:1234 STRING:9606.ENSP00000292303 UniGene:Hs.450802 , HGNC:1606 OMIM:601373 KEGG:hsa:1234 STRING:9606.ENSP00000292303 UniGene:Hs.450802
Function	Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
Pathway	Chemokine signaling pathway Endocytosis, Chemokine signaling pathway Endocytosis
Protein Families	G-protein coupled receptor 1 family
Tissue Specificity	Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557595	CSB-PA572290	100ul	$297		Add to Cart

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