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Home / Antibodies

CCND2 (Ab-280) Antibody

SKU : BHA10557698

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA931919
Alternative Names	cyclin D2; G1/S-specific cyclin D2;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.Xiong Y., Genomics 13:575-584(1992).Palmero I., Oncogene 8:1049-1054(1993).Kalnine N., Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human Cyclin D2 around the phosphorylation site of threonine 280 (A-S-T(p)-P-T).
Involvement In Disease	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity. Xiong Y., Genomics 13:575-584(1992). Palmero I., Oncogene 8:1049-1054(1993). Kalnine N., Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Cyclin D2 protein.
Subcellular Location	Nucleus, Cytoplasm, Membrane

Uniprot	P30279
Database Links	HGNC:1583 OMIM:123833 KEGG:hsa:894 STRING:9606.ENSP00000261254 UniGene:Hs.376071
Function	Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Pathway	Hedgehog signaling pathway Hippo signaling pathway Jak-STAT signaling pathway p53 signaling pathway PI3K-Akt signaling pathway Wnt signaling pathway Focal adhesion Cell cycle Cellular senescence FoxO signaling pathway
Protein Families	Cyclin family, Cyclin D subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557698	CSB-PA931919	100ul	$297		Add to Cart

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