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Home / Primary Antibodies

CAV1 (Ab-14) Antibody

SKU : BHA10557450

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA112716
Alternative Names	CAV; CAV1;
Categories	Primary Antibodies
Clonality	polyclonal
Description	The scaffolding protein encoded by Caveolin-1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (a and beta) are encoded by a single transcript from this gene.Zhang Y, et al. (2005) Mol Cell Proteomics. 4(9): 1240-1250.Labrecque L, et al. (2004) J Biol Chem. 279(50): 52132-52140.Fielding PE, et al. (2004) Biochemistry. 43(9): 2578-2586.Labrecque L, et al. (2003) Mol Biol Cell. 14(1): 334-347.Maggi D, et al. (2002) Biochem Biophys Res Commun. 295(5): 1085-1089.
Host	Rabbit
Immunogen	Peptide sequence around aa.12~16 (H-L-Y-T-V) derived from Human CAVEOLIN-1.
Involvement In Disease	Congenital generalized lipodystrophy 3 (CGL3); Pulmonary hypertension, primary, 3 (PPH3); Partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome (LCCNS)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The scaffolding protein encoded by Caveolin-1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (a and beta) are encoded by a single transcript from this gene. Zhang Y, et al. (2005) Mol Cell Proteomics. 4(9): 1240-1250. Labrecque L, et al. (2004) J Biol Chem. 279(50): 52132-52140. Fielding PE, et al. (2004) Biochemistry. 43(9): 2578-2586. Labrecque L, et al. (2003) Mol Biol Cell. 14(1): 334-347. Maggi D, et al. (2002) Biochem Biophys Res Commun. 295(5): 1085-1089.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total Caveolin-1 protein.
Subcellular Location	Golgi apparatus membrane, Peripheral membrane protein, Cell membrane, Peripheral membrane protein, Membrane, caveola, Peripheral membrane protein, Membrane raft, Golgi apparatus, trans-Golgi network

Uniprot	Q03135
Database Links	HGNC:1527 OMIM:601047 KEGG:hsa:857 STRING:9606.ENSP00000339191 UniGene:Hs.74034
Function	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation
Pathway	Focal adhesion Endocytosis Inflammatory Pain
Protein Families	Caveolin family
Tissue Specificity	Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557450	CSB-PA112716	100ul	$297		Add to Cart

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