CASP3 (Caspase 3) is a Protein Coding gene. Diseases associated with CASP3 include Lung Cancer and Nervous System Cancer. Among its related pathways are AGE/RAGE pathway and p75 NTR receptor-mediated signalling. The protein encoded by CASP3 is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Clonality
Polyclonal
Description
Rabbit Anti-Caspase 3 Polyclonal Antibody
Formulation
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen, Liquid solution
Host
Rabbit
Immunogen
Synthesized peptide derived from part region of human Caspase 3 protein
Immunogen Region
Synthesized peptide derived from part region of human Caspase 3 protein
Isotype
Rabbit IgG
Molecular Weight
34 KD
Others
This antibody detects endogenous levels of Caspase 3.
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Reactivity
Human, Mouse, Rat
Tag
Caspase 3
Note
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000-1:20000).
Accession Number
P42574
Gene Id
836, 836
Concentration
1 mg/ml, 1 mg/ml
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen, The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
Storage Buffer
PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol as stabilizer.
Storage Instructions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.