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Home / Antibodies

Caspase-10 Antibody (R30586)

SKU : BHA17104211

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NSJ Bioreagents

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Mfr.No.	R30586
Clonality	Polyclonal
Description	Caspase-10 is an enzyme that in humans is encoded by the CASP10 gene. The CASP10 gene contains 11 exons and spans about 48 kb. This gene is mapped to 2q33.1. It is transcribed in the centromere-to-telomere direction. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates CASP3 and 7, and the protein itself is processed by CASP8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alteatively spliced transcript variants encoding different isoforms have been described for this protein.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	Amino acids 220-236 (VKTFLEALPRAAVYRMN-human) were used as the immunogen for this Caspase-10 antibody. This sequence is from the large subunit
Isotype	IgG
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	Q92851

Buffer	Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the Caspase-10 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB
Dilution	Weste blot: 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104211	R30586	100 ug	$419		Add to Cart

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