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Home / Antibodies

CaMKK Antibody (R30595)

SKU : BHA17104216

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NSJ Bioreagents

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Mfr.No.	R30595
Clonality	Polyclonal
Description	Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent(CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. CaMKK binds calmodulin and activated Camk4 with a 6-fold increase in total activity and a 100-fold increase in Camk4 Ca(2+)-independent activity. It catalyzed a 10-fold increase in the total activity of CaMK1 and had no effect on CaMK2. Cotransfection of COS-7 cells with CaMKK and Camk4 resulted in a 14-fold increase in CRE-binding protein-dependent transcription compared with Camk4 alone, suggesting that CaMKK enhances Camk4-mediated transcriptional regulation.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	Amino acids 10-31 (QDPRAELVDRVAAINVAHLEEA-mouse) were used as the immunogen for this CaMKK antibody.
Isotype	IgG
Predicted Reactivity	Human, Mouse, Rat
Reactivity	Human, Mouse, Rat
Recombinant	No

Uniprot	Q8VBY2

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the CaMKK antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB, IHC-P
Dilution	Weste blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104216	R30595	100 ug	$419		Add to Cart

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