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Home / Primary Antibodies

Calcineurin Antibody / PPP3CA (V7515)

SKU : BHA17116429

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NSJ Bioreagents

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Mfr.No.	V7515, V7515-20UG, V7515-100UG
Antigen	Calcineurin
Clonality	Monoclonal
Description	Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
Formulation	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Host	Mouse
Immunogen Region	Full length recombinant human protein was used as the immunogen for the Calcineurin antibody.
Isotype	IgG1,kappa
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No
Subcellular Location	Cytoplasmic, cell surface

Uniprot	Q08209
Clone No	CALNA/2353

Concentration	0.2 mg/ml
Format	Purified
Purification	Protein G affinity
Storage	Store the Calcineurin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Applications	IHC-P
Dilution	Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17116429-1	V7515-20UG	20ug	$219		Add to Cart
BHA17116429-2	V7515-100UG	100ug	$499		Add to Cart

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