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Home / Primary Antibodies / Polyclonal Antibodies

Calcineurin A Antibody - SPC-175

BHA11907041
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Email
[email protected]
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Swissprot Q08209
Accession Number Q08209
Gene Id 5530
Target Calcineurin A
Research Area Cell Signaling, Post-translational Modifications, Phosphorylation
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), ICC/IF (1:120), IHC (1:100); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Scientific Background Calcineurin is a heterodimeric phosphatase protein, also known as calcium-dependent serine-threonine phosphatase. The structure consists of a catalytic subunit alpha, Calcineurin A (57-59KDa) the active site and a Ca2+ binding unit, Calcineurin B (19-20KDa) the regulatory subunit(1). Calcineurin plays a key role in the T-cell response growth and differentiation mechanism, regulating the activation of the Nuclear factor of activated T-cells (NFATc) which are important in the expression of IL-2 genes. Calcineurin has been the target of inhibitors, the novel and structural immune-suppressants antifungal drugs(2). Genetic studies in yeast and fungi established the molecular basis of the inhibition mechanism by cyclosporine A and FK506 (3).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~61kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, IP, WB, ICC/IF
Description WB ; IHC ; ICC ; IF ; IP
Dilution WB (1:1000), ICC/IF (1:120), IHC (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Rusnak F. and Mertz P. (2000) Physiol Rev. 80(4):1483-521.

2. Hemenway C.S. And Heitman J. (1999)Cell Biochem Biophys. 30(1):115-51.

3. Fox D.S. and Heitman J. (2002) Bioessays. 24(10):894-903.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11907041-1 SPC-175D Unconjugated 100 ug $306
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BHA11907041-2 SPC-175D-A390 ATTO 390 100 ug $360
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BHA11907041-3 SPC-175D-A488 ATTO 488 100 ug $359
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BHA11907041-4 SPC-175D-A594 ATTO 594 100 ug $359
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BHA11907041-5 SPC-175D-ALP Alkaline Phosphatase 100 ug $352
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BHA11907041-6 SPC-175D-APC APC 100 ug $358
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BHA11907041-7 SPC-175D-BI Biotin 100 ug $354
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BHA11907041-8 SPC-175D-FITC FITC 100 ug $350
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BHA11907041-9 SPC-175D-HRP HRP 100 ug $345
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BHA11907041-10 SPC-175D-PCP PerCP 100 ug $358
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BHA11907041-11 SPC-175D-RPE RPE 100 ug $355
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BHA11907041-12 SPC-175S Unconjugated 12 ug $44
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