This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
Formulation
In ascites with 0.09% sodium azide
Host
Mouse
Immunogen Region
This c-RET antibody was raised using purified His-tagged recombinant human c-RET.
Isotype
IgM,k
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Uniprot
P07949
Clone No
188CT11.2.3
Format
Ascites
Purification
Ascites
Storage
Aliquot the c-RET antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Applications
WB, IHC, IF, ELISA
Dilution
Western blot: 1:500-1:16000,IHC (Paraffin): 1:50-1:100,Immunofluorescence: 1:10-1:50