This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
Formulation
In ascites with 0.09% sodium azide
Host
Mouse
Immunogen Region
This c-RET antibody was raised using purified His-tagged recombinant human c-RET.
Isotype
Mouse IgM, k
Species Reactivity
Human
Note
Titration of the c-RET antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Uniprot
P07949
Format
Ascites
Purity
Ascites
Storage
Aliquot the c-RET antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.