Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.Sasada R., Biochem. Biophys. Res. Commun. 190:1173-1179(1993).Seno M., Growth Factors 13:181-191(1996).Miura K., Biochem. Biophys. Res. Commun. 294:1040-1046(2002).
Host
Rabbit
Immunogen
Synthesized peptide derived from Internal of Human BTC.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Sasada R., Biochem. Biophys. Res. Commun. 190:1173-1179(1993). Seno M., Growth Factors 13:181-191(1996). Miura K., Biochem. Biophys. Res. Commun. 294:1040-1046(2002).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total BTC protein.
Subcellular Location
Betacellulin: Secreted, extracellular space, SUBCELLULAR LOCATION: Probetacellulin: Cell membrane, Single-pass type I membrane protein
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Pathway
ErbB signaling pathway
Tissue Specificity
Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.