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Home / Antibodies

BRAF (Ab-753) Antibody

SKU : BHA10557696

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA921529
Alternative Names	B-RAF; B-RAF proto-oncogene serine/threonine-protein kinase; B-Raf proto-oncogene serine/threonine-protein kinase; BRAF; BRAF1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.Stephens R.M., Mol. Cell. Biol. 12:3733-3742(1992).Hillier L.W., Nature 424:157-164(2003).Eychene A., Oncogene 7:1657-1660(1992).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human B-Raf around the phosphorylation site of threonine 735 (P-K-T(p)-P-I).
Involvement In Disease	Colorectal cancer (CRC); Lung cancer (LNCR); Familial non-Hodgkin lymphoma (NHL); Cardiofaciocutaneous syndrome 1 (CFC1); Noonan syndrome 7 (NS7); LEOPARD syndrome 3 (LPRD3)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. Stephens R.M., Mol. Cell. Biol. 12:3733-3742(1992). Hillier L.W., Nature 424:157-164(2003). Eychene A., Oncogene 7:1657-1660(1992).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total B-Raf protein.
Subcellular Location	Nucleus, Cytoplasm, Cell membrane

Uniprot	P15056
Database Links	HGNC:1097 OMIM:114500 KEGG:hsa:673 STRING:9606.ENSP00000288602 UniGene:Hs.324250
Function	Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.
Pathway	cAMP signaling pathway Chemokine signaling pathway ErbB signaling pathway MAPK signaling pathway mTOR signaling pathway Focal adhesion Regulation of actin cytoskeleton Vascular smooth muscle contraction MAPK Erk pathway Natural killer cell mediated cytotoxicity FoxO signaling pathway Insulin signaling pathway Rap1 signaling pathway Neurotrophin signaling pathway
Protein Families	Protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily
Tissue Specificity	Brain and testis.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557696	CSB-PA921529	100ul	$297		Add to Cart

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